Villain rules

Villain rules the world and things became better. People started doubting heroes

A medium

A clairvoyant who can summon spirits

A family with mental illness

a family with mental illness and the character often worrying about whether he will inherit it.

Black death

A story based on black death and a doctor trying to find a cure for bubonic plague. he  may had to try the cure by infecting someone, probably his son. why didn't he take it is a question. it can also involve some patient's friend/family helping him in his quest.

Albino villain/friend

An albino friend or villain.

Personifying objects

we can personify simple objects and give them a mind of their own. like the ring in LOTR.

lady adventure

a lady dreams about going on for an adventure. her husband/father forbids her. she longs for it very much and then she is thrown into it. maybe it is to save her father/husband.

 

another character would be the diametrically opposite one. The mortally afraid one. Not wanting any adventure dragged into it.